Schistosomiasis remains the most important tropical snail-borne trematodiasis that\nthreatens many millions of human lives. In achieving schistosomiasis elimination targets,\nsustainable control of the snail vectors represents a logical approach. Nonetheless, the\nineffectiveness of the present snail control interventions emphasizes the need to develop new\ncomplementary strategies to ensure more effective control outcomes. Accordingly, the use of genetic\ntechniques aimed at driving resistance traits into natural vector populations has been put forward\nas a promising tool for integrated snail control. Leveraging the Biomphalaria-Schistosoma model\nsystem, studies unraveling the complexities of the vector biology and those exploring the molecular\nbasis of snail resistance to schistosome infection have been expanding in various breadths,\ngenerating many significant discoveries, and raising the hope for future breakthroughs. This review\nprovides a compendium of relevant findings, and without neglecting the current existing gaps and\npotential future challenges, discusses how a transgenic snail approach may be adapted and\nharnessed to control human schistosomiasis.
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